In 2021, the number of women running businesses on the Fortune 500 hit an all-time record: 41. But that’s not all. For the first time two Black women are running Fortune 500 businesses (Roz Brewer of No. 16 Walgreens Boots Alliance and Thasunda Brown Duckett of No. 79 TIAA). And another executive is making history at the helm of the highest-ranking business ever run by a female CEO (Karen Lynch of No. 4 CVS Health).