CareerWISE helps women in science, technology, engineering, and math (STEM) programs find ways to better manage the challenges in their immediate environments and expand personal skills for thriving in their future career environments. The CareerWISE resource is an individualized online program that pairs empirically based pedagogical content with an interactive simulated environment that provides users with practice opportunities. It is the first program of its kind to provide systematic training in interpersonal communication skills customized for female students in STEM. The program is built on an extensive foundation of theory and research on psychological processes, environmental context, and personal behaviors that contribute to women’s experiences in academic and career paths.